SCKs as nanoparticle carriers of doxorubicin: investigation of core composition on the loading, release and cytotoxicity profiles.

نویسندگان

  • Andreas M Nyström
  • Zhiqiang Xu
  • Jinqi Xu
  • Sara Taylor
  • Thalia Nittis
  • Sheila A Stewart
  • Jeffrey Leonard
  • Karen L Wooley
چکیده

SCK nanoparticles having differing core thermal characteristics were designed and evaluated as thermoresponsive drug delivery systems of doxorubicin for the killing of cancerous cells.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Anticancer Activity of Nanoparticles Based on PLGA and its Co-polymer: In-vitro Evaluation

Attempts have been made to prepare nanoparticles based on poly(lactic-co-glycolic acid) (PLGA) and doxorubicin. Biological evaluation and physio-chemical characterizations were performed to elucidate the effects of initial drug loading and polymer composition on nanoparticle properties and its antitumor activity. PLGA nanoparticles were formulated by sonication method. Lactide/glycolide ratio ...

متن کامل

Anticancer Activity of Nanoparticles Based on PLGA and its Co-polymer: In-vitro Evaluation

Attempts have been made to prepare nanoparticles based on poly(lactic-co-glycolic acid) (PLGA) and doxorubicin. Biological evaluation and physio-chemical characterizations were performed to elucidate the effects of initial drug loading and polymer composition on nanoparticle properties and its antitumor activity. PLGA nanoparticles were formulated by sonication method. Lactide/glycolide ratio ...

متن کامل

Investigation of cytotoxicity properties of zinc oxide nanoparticles in spherical and rod shaped on leukemia cells

In this study, we reported a method to associate doxorubicin drug on folic acid functionalized SiO2/ZnO nanoparticles (NPs) in rod and spherical shapes. The clinical usage of the anticancer drug, doxorubicin (DOX), is limited by severe side effects and cell resistance. Targeted drug delivery by binding DOX to nanoparticles could overcome these limitations. The surface functionalization of the Z...

متن کامل

ارزیابی اثر شارژ سطحی دوکسوربیسین لیپوزومه بر روی سمیت سلولی رده سرطان استخوان (استئوسارکوما)

Background and Objective: In the present study, PEGylated liposomal formulation containing doxorubicin was synthesized in order to study the effects of surface charge on its cytotoxicity.   Materials and Methods: Liposomal doxorubicin containing DPPC, cholesterol and phospholipid DSPE-mPEG with various amounts of cationic phospholipid, DOTAP, (0, 5.2 and 20%) was prepared by pH gradient ...

متن کامل

Dual Nano-Carriers using Polylactide-block-Poly(N-isopropylacrylamide-random-acrylic acid) Polymerized from Reduced Graphene Oxide Surface for Doxorubicin Delivery Applications

The stimuli-responsive nanocomposites were designed as drug delivery nanocarriers. Thanks to promising properties such as large surface area and easy chemical functionalization, the graphene derivatives can be used for the drug delivery applications. For this purpose, in the current work, the poly(L,D-lactide)-block-poly(N-isopropylacrylamide-rand-acrylic acid) grafted from reduced graphene oxi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Chemical communications

دوره 30  شماره 

صفحات  -

تاریخ انتشار 2008